Modern cells are complex chemical entities with cytoskeletons, finely regulated internal and external molecules, and genetic material that determines nearly every aspect of their functioning. This ...

A genomic atlas of Nematostella vectensis reveals how primitive animals created multiple cell types millions of years ago, ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

A recent review by Carlo Maley, a researcher at Arizona State University, and Lucie Laplane from the University of Paris Pantheon-Sorbonne critiques the dominant theory of cancer evolution. The ...

In a study published in Developmental Cell, a team led by Prof. Robert K. Naumann from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences (CAS), and researchers from BGI ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

Thought too hard to do, a new platform evolved proteins in mammalian cells, which could help researchers design drugs that work better in humans. “There are many, many examples, both published and ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

Germinal centers are engines of rapid evolution. These tiny clusters in the lymph nodes refine antibodies through proliferation and mutation, generating high-affinity B cells capable of controlling ...