但在初步测试中,这种原始设计的表现并不尽如人意。数据显示,虽然它能用于驱动荧光素酶发光来检测出血,但其产生的生物活性分子数量远远不足以达到治疗阈值。更致命的是,其信噪比(Signal-to-noise ratio)较低,这意味着在没有出血的健康肠道中,细菌也可能发生“泄漏”表达,导致非特异性的药物释放。
在急性结肠炎模型和慢性结肠炎模型中,该智能活胶水均表现出良好的体内治疗效果。研究结果显示,该体系仅在疾病状态下被激活,并可在病灶区域实现稳定、持久的基因编码型生物黏附;单次给药后,其治疗作用可持续超过 10 ...
Transverse colon samples from confirmed Alzheimer’s disease cases showed distinct gut microbiome and proteomic shifts, including higher amyloid beta 42 and microbial patterns associated with plaque ...
The ‘TL1A’ messenger protein of the immune system triggers gut-to-bone marrow reaction, increasing the colorectal cancer risk ...
Your belly hurts. The diarrhea keeps coming. And you certainly don’t feel like eating. These are telltale signs of colitis. But which kind? Colitis is a term used to describe inflammation in your ...
One doctor suggests easing colonoscopy concerns by sharing the experience. Oct. 20, 2008 — -- Hardly a week goes by that I don't hear about someone losing the battle to colon cancer. And each and ...
The gut-brain connection is a complicated two-way signaling cascade that is responsible for keeping the digestive system working properly and can cause problems when it breaks down. A key part of that ...
Water is often dubbed the elixir of life, and for a good reason. It is a crucial component of our bodies, making up about 60 percent of our total body weight. Every cell, tissue and organ in our body ...