Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

University of Michigan researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons. These chemicals are among a wide variety of signals ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

The GPCR-targeting therapies market is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with cancer, the growing awareness ...